EVALUATING APREPITANT SINGLE-DOSE PLUS GRANISETRON AND DEXAMETHASONE IN CHILDREN RECEIVING HIGHLY EMETOGENIC CHEMOTHERAPY FOR THE PREVENTION OF CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING: A TRIPLE-BLINDED RANDOMIZED CLINICAL TRIAL

Evaluating Aprepitant single-dose plus granisetron and dexamethasone in children receiving highly emetogenic chemotherapy for the prevention of chemotherapy-induced nausea and vomiting: A triple-blinded randomized clinical trial

Introduction: This study was performed to evaluate the degree of 3-day chemotherapy-induced nausea and vomiting (CINV) in children with cancer who received highly emetogenic chemotherapy (HEC) to ascertain the efficacy of aprepitant single-dose on dayL 1 plus granisetron and dexamethasone (DEX).Methods: This clinical trial study was conducted on 12

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Modeling Approaches to Assess Soil Erosion by Water at the Field Scale with Special Emphasis on Heterogeneity of Soils and Crops

Information on soil erosion and related sedimentation processes are very important for natural resource management and sustainable farming.Plenty of models are available for studying soil erosion but only a few are suitable for dynamic soil erosion assessments at the field-scale.To date, there are no field-scale dynamic models available considering

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MCU-independent Ca2+ uptake mediates mitochondrial Ca2+ overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy

Abstract Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major contributor to several human diseases.Indeed, Duchenne muscular dystrophy (MD) is driven by dysfunctional Ca2+ influx across the sarcolemma that causes mitochondrial Ca2+ overload, organelle rupture, and muscle necrosis.The mitochondrial Ca2+ uniporter (MCU)

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